(2R)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxy-N-(1-methylethyl)propan-1-aminium
Atenolol
CAS: 29122-68-7;60966-51-0
Molecular Formula: C14H22N2O3
(2R)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxy-N-(1-methylethyl)propan-1-aminium - Names and Identifiers
| Name | Atenolol |
| Synonyms | Atenolo Atenolol (+-)-Atenolol 2-[4-(2-hydroxy-3-isopropylaminopropoxy)phenyl]acetamide (+-)-4-(2-Hydroxy-3-isopropylaminopropoxy)phenylacetamide ()-2-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide (±)-2-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide (1)-2-(4-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide 2-(4-{[(2S)-2-hydroxy-3-(propan-2-ylamino)propyl]oxy}phenyl)acetamide Benzeneacetamide, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, (+-)- (2S)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxy-N-(1-methylethyl)propan-1-aminium (2R)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxy-N-(1-methylethyl)propan-1-aminium |
| CAS | 29122-68-7 60966-51-0 |
| EINECS | 262-544-7 |
| InChI | InChI=1/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)/p+1/t12-/m0/s1 |
(2R)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxy-N-(1-methylethyl)propan-1-aminium - Physico-chemical Properties
| Molecular Formula | C14H22N2O3 |
| Molar Mass | 266.33608 |
| Boling Point | 508°C at 760 mmHg |
| Flash Point | 261.1°C |
| Vapor Presure | 3.82E-11mmHg at 25°C |
| Physical and Chemical Properties | White crystalline powder. Slightly odorous, slightly soluble in water, chloroform, soluble in ethanol, almost insoluble in ether. Melting point 150-152 °c. Selective beta-blockers, without myocardial inhibitory effect. |
| Use | For the treatment of hypertension, angina and arrhythmia, glaucoma intraocular pressure control. |
(2R)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxy-N-(1-methylethyl)propan-1-aminium - Upstream Downstream Industry
| Raw Materials | 4'-Hydroxyacetophenone |
(2R)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxy-N-(1-methylethyl)propan-1-aminium - Standard
Authoritative Data Verified Data
This product is 4-[3-(2-hydroxy-3-isopropylamino) propoxy] phenylacetamide. The content of C14H22N203 shall be between 98.0% and 102.0% based on the dry product.
Last Update：2024-01-02 23:10:35
(2R)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxy-N-(1-methylethyl)propan-1-aminium - Trait
Authoritative Data Verified Data
- This product is white powder; Odorless or slightly odorous.
- This product is dissolved in ethanol, slightly soluble in chloroform or water, and almost insoluble in ether.
melting point
The melting point of this product (General 0612) is 151~155°C.
Last Update：2022-01-01 13:31:51
(2R)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxy-N-(1-methylethyl)propan-1-aminium - Differential diagnosis
Authoritative Data Verified Data
- take this product, add anhydrous ethanol to make a solution containing 10ug per lml, according to UV-visible spectrophotometry (General 0401), at 227nm, 276mn has maximum absorption at the wavelength of 283nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 214).
Last Update：2022-01-01 13:31:51
(2R)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxy-N-(1-methylethyl)propan-1-aminium - Exam
Authoritative Data Verified Data
clarity of the solution
take 50mg of this product, add 10ml of water and 5ml of dilute hydrochloric acid to dissolve, and the solution should be clear.
Related substances
take about 10mg of this product, put it in a 100ml measuring flask, add an appropriate amount of mobile phase, ultrasonic to dissolve and dilute to the scale, shake well, as a test solution; Take 1ml for precision measurement, set in a 100ml measuring flask, dilute to the scale with the mobile phase, and shake to serve as a control solution. According to the chromatographic conditions under the content determination item, 20 u1 of each of the test solution and the control solution are accurately measured and injected into the human liquid chromatograph respectively, and the chromatogram is recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Last Update：2022-01-01 13:31:52
(2R)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxy-N-(1-methylethyl)propan-1-aminium - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel bonded with octylsilane as filler; Phosphate buffer solution (6.8g of potassium dihydrogen phosphate, 1.3g of sodium octane sulfonate, dissolved in water and diluted to 3.0 ML, adjusted to pH with phosphoric acid)-Fermentation broth (70:30) as mobile phase; Detection wavelength 226mn. The number of theoretical plates shall not be less than 2000 based on the Atenolol peak. The degree of separation of the Atenolol peak from the adjacent impurity peak should meet the requirements.
assay
take about 25mg of this product, put it in a 100ml measuring flask, add an appropriate amount of mobile phase, ultrasonic to dissolve and dilute to the scale, shake well, take 2ml with precision, put it in a 10ml measuring flask, dilute it to scale with mobile phase, shake well, inject 20ul into the liquid chromatograph with precision, record the chromatogram; Take the reference substance of atenolol, and determine with the same method. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 13:31:53
(2R)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxy-N-(1-methylethyl)propan-1-aminium - Category
Authoritative Data Verified Data
B adrenergic receptor blockers.
Last Update：2022-01-01 13:31:53
(2R)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxy-N-(1-methylethyl)propan-1-aminium - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 13:31:53
(2R)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxy-N-(1-methylethyl)propan-1-aminium - Atenolol tablets
Authoritative Data Verified Data
This product contains Atenolol (C14H22N203) should be 90.0% ~ 110.0% of the label amount.
trait
This product is a white tablet or sugar-coated tablet, White after removing the coating.
identification
- The product was taken, and anhydrous ethanol was added to prepare a solution containing about lOug of atenolol per 1 ml, and the same results were obtained according to the identification (1) Test under the item of Atenolol.
- in the chromatogram recorded under the content determination item, the retention time of the main Bee of the test solution should be consistent with the retention time of the main peak of the control solution.
examination
- appropriate amount of fine powder (equivalent to 10mg of atenolol) under the content determination item, put it in a 100ml measuring flask, add appropriate amount of mobile phase, sonicate to dissolve atenolol, and dilute to the scale with mobile phase, shake well, filter, and take the continued filtrate as the test solution; Take 1 ml with precision, put it in a 100ml measuring flask, dilute to the scale with mobile phase, shake well, and use as the control solution. If there are impurity peaks (except the solvent peak and the previous peaks) in the chromatogram of the test solution determined according to the method of related substances of atenolol, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
- dissolution the dissolution of this product was determined according to the dissolution and release determination method (General 0931 second method), with hydrochloric acid solution (9-l000)l000ml as the dissolution medium, and the rotation speed was 50 revolutions per minute, operate according to the law, after 45 minutes, take 10ml of solution, filter, take the appropriate amount of filtrate, dilute quantitatively with dissolution medium to make about 10% of atenolol solution per lml, according to UV-visible spectrophotometry (General rule 0401), measure absorbance at the wavelength of 224nm; Take appropriate amount of atenolol reference, the dissolution medium was added to dissolve and quantitatively dilute to prepare a solution containing about 10ug per 1 ml, and the dissolution amount of each tablet was calculated by the same method. The limit is 70% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product (sugar-coated tablets should be removed from the coating), precise weighing, fine grinding, precise weighing fine powder appropriate amount (equivalent to Atenolol 25mg), put in 100ml measuring flask, add appropriate amount of mobile phase, ultrasonic to dissolve atenolol and dilute it to scale, shake well, filter, take 2ml of continued filtrate precisely, put it in 10ml measuring flask, dilute it to scale with mobile phase, shake well, as the test solution, according to the method under the item of atenolol content determination, it is obtained.
category storage
Same as Atenolol.
specification
(1)12.5mg (2)25mg (3)50mg (4)100mg
Last Update：2022-01-01 13:31:54
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Product Name: Atenolol Visit Supplier Webpage Request for quotationCAS: 29122-68-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Atenolol Request for quotation
CAS: 29122-68-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 29122-68-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
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Raw Materials for (2R)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxy-N-(1-methylethyl)propan-1-aminium